This issue delves into the evolving discourse surrounding One Health, especially in the aftermath of the recent global pandemic. While international conversations and policy frameworks highlight the interconnectedness of human, animal, and environmental health, there is a growing concern about the practical implementation and the dominance of anthropocentric perspectives. This issue aims to challenge these constructs by focusing on real-world experiences and challenges faced by different communities and foster a decolonized narrative that empowers stakeholders and communities to navigate the complexities of One Health effectively.